Two forms of the same active. B2B raw material for further formulation. Documentation and samples on request.
RAW MATERIAL · AVAILABLE FROM STOCK
What it is: A standardized xanthohumol extract from hops (Humulus lupulus L.), supplied as a yellow-orange powder. It is standardized to roughly 90 to 95% XN, and the exact content of every batch is confirmed by its own analytical report. Our reference material, for instance, was standardized to 94.7% XN. This is a standardized extract, not an isolated reference compound.
Who it is for: Teams that want to work with the active directly, inside their own formula or delivery system. It fits anhydrous formats, treatments, concentrated systems and any project where you would rather engineer the delivery yourself.
Documentation: Each supply can come with an analytical (quantitative) report, an SDS and a product specification. The numbers describe the specific batch, not an average. Each production batch is approximately 0.5 kg. Held in stock, so there is no multi-week wait for production or import. Documentation confirms quality and parameters.
TECHNOLOGICAL FORM · MADE TO ORDER
What it is: A liposomal form of xanthohumol for teams that want a delivery-oriented format without building a liposomal system from scratch. In its native form xanthohumol is poorly water soluble, which limits how it can be worked into a formula. The liposomal form is designed to support stability and delivery-oriented use in products such as serums, creams and O/W emulsions. Final compatibility depends on your formulation.
To our knowledge, we are currently the only producer in Europe offering liposomal xanthohumol as a B2B raw material, rather than only as an ingredient inside its own finished product.
We produce liposomal orders individually, to order, on the same substrates, technology and controlled process as our reference batch P2. That way we avoid long storage and overproduction, and each batch is prepared as fresh as possible.
Our recommended formulation currently sits at roughly 0.55 to 0.75% XN, a range we find sound for stability and practical use in cosmetics. These values are indicative. We share them as the range we consider best suited to beauty products, not as a fixed spec. We can also prepare the liposomal form to the parameters a given partner needs, agreed case by case. Particle size and PDI are documented by TEM/DLS for the reference batch and shared on request.
For reference batch P2 and its raw materials we can provide microbiological analysis, water activity, quantitative XN content in the liposomal formulation, a TEM/DLS report with specification, SDS for the components used, and the quantitative report, specification and SDS for the source extract (standardized to 94.7% XN).
For smaller orders, we provide the full documentation package from our reference batch, the same set of tests listed above. Every order is produced on three principles that stay constant: our own proprietary technology, the same components, and controlled production conditions.
If you need dedicated testing on your own material, we can prepare a made to order pilot batch with the listed tests as a separately priced package, and larger orders can include the full test package. Exact volumes and terms are agreed per project. Documentation confirms quality and parameters.
As an antioxidant it performs at the top of its class. Its free-radical neutralising capacity has been benchmarked against Trolox, the industry reference standard, and it works on two levels at once: quenching reactive species directly, and activating Nrf2/ARE, the cell's own master switch for antioxidant and cytoprotective defence.
Its anti-inflammatory signature is just as distinctive. Xanthohumol acts on the NF-κB pathway and the pro-inflammatory cytokines that drive it, IL-1β, IL-6 and TNF-α, the same signalling network behind redness, irritation and inflammaging in the skin.
Beyond direct antioxidant action, it is also studied for activating phase II and detoxifying enzymes, such as NAD(P)H:quinone oxidoreductase and heme oxygenase-1, part of the cell's broader defence system.
And there is one catch, which is exactly where we come in. In its native form xanthohumol is poorly water soluble, which has long kept this powerful molecule out of reach for modern formulations. Our liposomal encapsulation changes that: it stabilises the active, protects it against oxidation and light, and makes it ready to integrate into serums, emulsions and dermocosmetic systems, so its full potential can finally be put to work in a real product.
Sources: Antioxidants (Basel) 2024;13(12):1559 — doi.org/10.3390/antiox13121559 · J Agric Food Chem 2015 — doi.org/10.1021/jf505075n · PMID 21093515 — pubmed.ncbi.nlm.nih.gov/21093515 · PMID 18952893 — pubmed.ncbi.nlm.nih.gov/18952893
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